Detailed information of TA system TA266112

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2611770..2612189
• Replicon: chromosome
• Accession: NZ_CP113832
• Organism: Enterococcus faecalis strain M61

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OZF29_RS12665
• Protein ID: WP_023894767.1
• Coordinates: 2612085..2612189 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2611770..2611910 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OZF29_RS12650 (2607332)	2607332..2608045	-	714	WP_002354877.1	trehalose operon repressor	-
OZF29_RS12655 (2608306)	2608306..2611050	+	2745	WP_116495149.1	glycosyl hydrolase family 65 protein	-
OZF29_RS12660 (2611065)	2611065..2611715	+	651	WP_002415627.1	beta-phosphoglucomutase	-
- (2611770)	2611770..2611910	+	141	NuclAT_6	-	Antitoxin
- (2611966)	2611966..2612107	+	142	NuclAT_16	-	-
- (2611966)	2611966..2612152	+	187	NuclAT_1	-	-
OZF29_RS12665 (2612085)	2612085..2612189	-	105	WP_023894767.1	putative holin-like toxin	Toxin
- (2612341)	2612341..2612475	+	135	NuclAT_17	-	-
- (2612329)	2612329..2612478	+	150	NuclAT_3	-	-
OZF29_RS12670 (2612751)	2612751..2613344	+	594	WP_161970597.1	PBECR4 domain-containing protein	-
- (2613467)	2613467..2613607	+	141	NuclAT_4	-	-
OZF29_RS12675 (2614106)	2614106..2614639	+	534	WP_002416003.1	CPBP family intramembrane metalloprotease	-
OZF29_RS12680 (2614693)	2614693..2615664	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
OZF29_RS12685 (2615839)	2615839..2616276	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
OZF29_RS12690 (2616409)	2616409..2616963	-	555	WP_002378827.1	nucleoside triphosphate pyrophosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T266112 WP_023894767.1 NZ_CP113832:c2612189-2612085 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 141 bp

>AT266112 NZ_CP113832:2611770-2611910 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACGTACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTTGA
ATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA

Structures

Antitoxin