Detailed information of TA system TA266110

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2547981..2548240
• Replicon: chromosome
• Accession: NZ_CP113832
• Organism: Enterococcus faecalis strain M61

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OZF29_RS12370
• Protein ID: WP_021164442.1
• Coordinates: 2548139..2548240 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2547981..2548185 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OZF29_RS12340 (2543234)	2543234..2544187	-	954	WP_116495158.1	siderophore ABC transporter substrate-binding protein	-
OZF29_RS12345 (2544226)	2544226..2544981	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
OZF29_RS12350 (2544978)	2544978..2545943	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
OZF29_RS12355 (2545940)	2545940..2546887	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
OZF29_RS12360 (2547071)	2547071..2547523	+	453	WP_010707017.1	YueI family protein	-
- (2547549)	2547549..2547756	+	208	NuclAT_11	-	-
- (2547586)	2547586..2547760	+	175	NuclAT_20	-	-
OZF29_RS12365 (2547705)	2547705..2547806	-	102	WP_228088368.1	putative holin-like toxin	-
- (2547981)	2547981..2548185	+	205	NuclAT_12	-	Antitoxin
- (2548015)	2548015..2548202	+	188	NuclAT_19	-	-
OZF29_RS12370 (2548139)	2548139..2548240	-	102	WP_021164442.1	putative holin-like toxin	Toxin
OZF29_RS12375 (2548431)	2548431..2550701	-	2271	WP_116495157.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
OZF29_RS12380 (2550872)	2550872..2551372	+	501	WP_002378961.1	cysteine hydrolase family protein	-
OZF29_RS12385 (2551718)	2551718..2552614	+	897	WP_002354953.1	YitT family protein	-
OZF29_RS12390 (2552665)	2552665..2553063	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T266110 WP_021164442.1 NZ_CP113832:c2548240-2548139 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 205 bp

>AT266110 NZ_CP113832:2547981-2548185 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGTGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin