Detailed information of TA system TA026610

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF4/-
• Location: 2042254..2042553
• Replicon: chromosome
• Accession: NC_017338
• Organism: Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAA6159_RS14810
• Protein ID: WP_011447039.1
• Coordinates: 2042377..2042553 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2042254..2042309 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAA6159_RS10120	2037585..2037845	+	261	WP_001791826.1	hypothetical protein	-
SAA6159_RS10125	2037898..2038248	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAA6159_RS10130	2038933..2039382	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAA6159_RS15145	2039477..2039812	-	336	Protein_1921	SH3 domain-containing protein	-
SAA6159_RS10140	2040462..2040953	-	492	WP_000919350.1	staphylokinase	-
SAA6159_RS10145	2041144..2041899	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAA6159_RS10150	2041911..2042165	-	255	WP_000611512.1	phage holin	-
SAA6159_RS10155	2042217..2042324	+	108	WP_001791821.1	hypothetical protein	-
-	2042246..2042385	+	140	NuclAT_0	-	-
-	2042246..2042385	+	140	NuclAT_0	-	-
-	2042246..2042385	+	140	NuclAT_0	-	-
-	2042246..2042385	+	140	NuclAT_0	-	-
-	2042254..2042309	+	56	-	-	Antitoxin
SAA6159_RS14810	2042377..2042553	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAA6159_RS10165	2042703..2042999	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAA6159_RS10170	2043057..2043344	-	288	WP_001040261.1	hypothetical protein	-
SAA6159_RS10175	2043391..2043543	-	153	WP_001153681.1	hypothetical protein	-
SAA6159_RS10180	2043533..2047318	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2037898..2088923	51025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T26610 WP_011447039.1 NC_017338:c2042553-2042377 [Staphylococcus aureus subsp. aureus JKD6159]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T26610 NC_017338:c2042553-2042377 [Staphylococcus aureus subsp. aureus JKD6159]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT26610 NC_017338:2042254-2042309 [Staphylococcus aureus subsp. aureus JKD6159]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin