Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2854918..2855192 Replicon chromosome
Accession NZ_CP113831
Organism Enterococcus faecalis strain T30

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag OZE10_RS14505 Protein ID WP_002392696.1
Coordinates 2855049..2855192 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2854918..2855116 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE10_RS14485 (2849920) 2849920..2850633 - 714 WP_002367455.1 trehalose operon repressor -
OZE10_RS14490 (2850895) 2850895..2853639 + 2745 WP_047648974.1 glycosyl hydrolase family 65 protein -
OZE10_RS14495 (2853654) 2853654..2854304 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2854359) 2854359..2854499 + 141 NuclAT_10 - -
- (2854555) 2854555..2854700 + 146 NuclAT_12 - -
- (2854555) 2854555..2854741 + 187 NuclAT_9 - -
OZE10_RS14500 (2854674) 2854674..2854778 - 105 WP_023894767.1 putative holin-like toxin -
- (2854930) 2854930..2855075 + 146 NuclAT_13 - -
- (2854918) 2854918..2855116 + 199 NuclAT_8 - Antitoxin
OZE10_RS14505 (2855049) 2855049..2855192 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
OZE10_RS14510 (2855424) 2855424..2856395 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
OZE10_RS14515 (2856570) 2856570..2857007 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
OZE10_RS14520 (2857140) 2857140..2857694 - 555 WP_002354869.1 Maf family protein -
OZE10_RS14525 (2857719) 2857719..2859851 - 2133 WP_002378991.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T266096 WP_002392696.1 NZ_CP113831:c2855192-2855049 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT266096 NZ_CP113831:2854918-2855116 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References