Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1648117..1648763 Replicon chromosome
Accession NZ_CP113789
Organism Klebsiella variicola subsp. tropica strain BSK_177V2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OUI59_RS08200 Protein ID WP_074387047.1
Coordinates 1648416..1648763 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OUI59_RS08195 Protein ID WP_074387048.1
Coordinates 1648117..1648416 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUI59_RS08175 (OUI59_08175) 1644324..1645082 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
OUI59_RS08180 (OUI59_08180) 1645132..1645962 - 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
OUI59_RS08185 (OUI59_08185) 1646013..1646342 - 330 WP_032733885.1 thiosulfate sulfurtransferase GlpE -
OUI59_RS08190 (OUI59_08190) 1646546..1648054 + 1509 WP_074387049.1 glycerol-3-phosphate dehydrogenase -
OUI59_RS08195 (OUI59_08195) 1648117..1648416 - 300 WP_074387048.1 XRE family transcriptional regulator Antitoxin
OUI59_RS08200 (OUI59_08200) 1648416..1648763 - 348 WP_074387047.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OUI59_RS08205 (OUI59_08205) 1648978..1651425 - 2448 WP_061153092.1 glycogen phosphorylase -
OUI59_RS08210 (OUI59_08210) 1651443..1652876 - 1434 WP_061153091.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.59 Da        Isoelectric Point: 6.7217

>T266045 WP_074387047.1 NZ_CP113789:c1648763-1648416 [Klebsiella variicola subsp. tropica]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
ILCAGNKDGMNEKRFYKEMITLADREFSKHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10853.63 Da        Isoelectric Point: 10.1464

>AT266045 WP_074387048.1 NZ_CP113789:c1648416-1648117 [Klebsiella variicola subsp. tropica]
MATLKELMAKQNPESQQRIAAKAAEIRQSVALNLLREELQISQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References