266039

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3635996..3636558 Replicon chromosome
Accession NZ_CP113784
Organism Citrobacter freundii strain CFSAN077772

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OW080_RS17265 Protein ID WP_032936429.1
Coordinates 3635996..3636274 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B5QC60
Locus tag OW080_RS17270 Protein ID WP_003836231.1
Coordinates 3636274..3636558 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW080_RS17245 (3631113) 3631113..3631544 - 432 WP_003020036.1 peroxiredoxin OsmC -
OW080_RS17250 (3631772) 3631772..3631912 + 141 WP_003020039.1 stationary-phase-induced ribosome-associated protein -
OW080_RS17255 (3632092) 3632092..3633789 + 1698 WP_003020042.1 malate dehydrogenase -
OW080_RS17260 (3634099) 3634099..3635814 + 1716 WP_032935731.1 ABC-F family ATP-binding cassette domain-containing protein -
OW080_RS17265 (3635996) 3635996..3636274 + 279 WP_032936429.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OW080_RS17270 (3636274) 3636274..3636558 + 285 WP_003836231.1 HigA family addiction module antitoxin Antitoxin
OW080_RS17275 (3636602) 3636602..3637204 - 603 WP_071701181.1 inorganic diphosphatase -
OW080_RS17280 (3637334) 3637334..3637990 - 657 WP_032935728.1 formate dehydrogenase-N subunit gamma -
OW080_RS17285 (3637983) 3637983..3638867 - 885 WP_003833024.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10667.30 Da        Isoelectric Point: 9.8965

>T266039 WP_032936429.1 NZ_CP113784:3635996-3636274 [Citrobacter freundii]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGDRDGIWAITVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10358.10 Da        Isoelectric Point: 8.8094

>AT266039 WP_003836231.1 NZ_CP113784:3636274-3636558 [Citrobacter freundii]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQTTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5QC60

References