26603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2556322..2556845 Replicon chromosome
Accession NC_017337
Organism Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SAOV_RS13200 Protein ID WP_000074048.1
Coordinates 2556322..2556588 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag SAOV_RS13205 Protein ID WP_000587620.1
Coordinates 2556588..2556845 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOV_RS13180 2551532..2552719 - 1188 WP_000026189.1 MFS transporter -
SAOV_RS13185 2553114..2553890 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
SAOV_RS13190 2553883..2554545 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
SAOV_RS13195 2554890..2555966 - 1077 WP_001076674.1 M42 family metallopeptidase -
SAOV_RS13200 2556322..2556588 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SAOV_RS13205 2556588..2556845 - 258 WP_000587620.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAOV_RS13215 2557206..2557673 + 468 WP_000732083.1 YehR family lipoprotein -
SAOV_RS13220 2557829..2559406 - 1578 WP_000143507.1 FMN-binding glutamate synthase family protein -
SAOV_RS13225 2559600..2560349 + 750 WP_000072455.1 CPBP family intramembrane metalloprotease -
SAOV_RS13230 2560573..2561766 - 1194 WP_000675398.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T26603 WP_000074048.1 NC_017337:c2556588-2556322 [Staphylococcus aureus subsp. aureus ED133]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T26603 NC_017337:c2556588-2556322 [Staphylococcus aureus subsp. aureus ED133]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9675.65 Da        Isoelectric Point: 4.1958

>AT26603 WP_000587620.1 NC_017337:c2556845-2556588 [Staphylococcus aureus subsp. aureus ED133]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQGTIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT26603 NC_017337:c2556845-2556588 [Staphylococcus aureus subsp. aureus ED133]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGGGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure

References