Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4647194..4647796 Replicon chromosome
Accession NZ_CP113541
Organism Salmonella enterica strain CHC

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag OXV05_RS22340 Protein ID WP_001159630.1
Coordinates 4647485..4647796 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV05_RS22335 Protein ID WP_000362050.1
Coordinates 4647194..4647484 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV05_RS22320 (4644687) 4644687..4645589 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OXV05_RS22325 (4645586) 4645586..4646221 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV05_RS22330 (4646218) 4646218..4647147 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OXV05_RS22335 (4647194) 4647194..4647484 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV05_RS22340 (4647485) 4647485..4647796 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OXV05_RS22345 (4648014) 4648014..4648943 + 930 WP_001127703.1 alpha/beta hydrolase -
OXV05_RS22350 (4649029) 4649029..4649340 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OXV05_RS22355 (4649337) 4649337..4649783 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OXV05_RS22360 (4649798) 4649798..4650739 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV05_RS22365 (4650784) 4650784..4651221 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
OXV05_RS22370 (4651218) 4651218..4652090 - 873 WP_000921427.1 virulence factor BrkB family protein -
OXV05_RS22375 (4652084) 4652084..4652683 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T266023 WP_001159630.1 NZ_CP113541:c4647796-4647485 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT266023 WP_000362050.1 NZ_CP113541:c4647484-4647194 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References