266016

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2384926..2385448 Replicon chromosome
Accession NZ_CP113541
Organism Salmonella enterica strain CHC

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OXV05_RS11465 Protein ID WP_000221343.1
Coordinates 2385164..2385448 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OXV05_RS11460 Protein ID WP_000885424.1
Coordinates 2384926..2385174 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV05_RS11435 (2380142) 2380142..2381608 + 1467 WP_000987828.1 hypothetical protein -
OXV05_RS11440 (2382416) 2382416..2383130 + 715 Protein_2236 helix-turn-helix domain-containing protein -
OXV05_RS11445 (2383186) 2383186..2384094 - 909 WP_010989018.1 hypothetical protein -
OXV05_RS11450 (2384237) 2384237..2384569 - 333 WP_198903240.1 DUF1493 family protein -
OXV05_RS11455 (2384559) 2384559..2384774 - 216 WP_000206207.1 hypothetical protein -
OXV05_RS11460 (2384926) 2384926..2385174 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OXV05_RS11465 (2385164) 2385164..2385448 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXV05_RS11470 (2385619) 2385619..2386008 + 390 WP_000194089.1 RidA family protein -
OXV05_RS11475 (2386060) 2386060..2387139 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OXV05_RS11480 (2387332) 2387332..2387820 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
OXV05_RS11485 (2387865) 2387865..2389373 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2380145..2392230 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T266016 WP_000221343.1 NZ_CP113541:2385164-2385448 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT266016 WP_000885424.1 NZ_CP113541:2384926-2385174 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References