Detailed information of TA system TA026601

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2525003..2525187
• Replicon: chromosome
• Accession: NC_017337
• Organism: Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: SAOV_RS13045
• Protein ID: WP_000482647.1
• Coordinates: 2525080..2525187 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2525003..2525063 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOV_RS13020	2520457..2520624	-	168	WP_041204334.1	hypothetical protein	-
SAOV_RS13030	2520855..2522588	-	1734	WP_000486497.1	ABC transporter ATP-binding protein/permease	-
SAOV_RS13035	2522613..2524376	-	1764	WP_001064817.1	ABC transporter ATP-binding protein/permease	-
-	2525003..2525063	+	61	-	-	Antitoxin
SAOV_RS13045	2525080..2525187	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
SAOV_RS13050	2525320..2525706	-	387	WP_000779350.1	flippase GtxA	-
SAOV_RS13055	2525974..2527116	+	1143	WP_001176868.1	glycerate kinase	-
SAOV_RS13060	2527176..2527835	+	660	WP_000831299.1	hypothetical protein	-
SAOV_RS13065	2528021..2529232	+	1212	WP_001191928.1	multidrug effflux MFS transporter	-
SAOV_RS13070	2529355..2529828	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T26601 WP_000482647.1 NC_017337:c2525187-2525080 [Staphylococcus aureus subsp. aureus ED133]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T26601 NC_017337:c2525187-2525080 [Staphylococcus aureus subsp. aureus ED133]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT26601 NC_017337:2525003-2525063 [Staphylococcus aureus subsp. aureus ED133]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin