266004

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4522709..4523311 Replicon chromosome
Accession NZ_CP113540
Organism Salmonella enterica strain CYX

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag OXV10_RS22050 Protein ID WP_001159635.1
Coordinates 4523000..4523311 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV10_RS22045 Protein ID WP_000362050.1
Coordinates 4522709..4522999 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV10_RS22030 (4520202) 4520202..4521104 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
OXV10_RS22035 (4521101) 4521101..4521736 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV10_RS22040 (4521733) 4521733..4522662 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
OXV10_RS22045 (4522709) 4522709..4522999 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV10_RS22050 (4523000) 4523000..4523311 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OXV10_RS22055 (4523529) 4523529..4524458 + 930 WP_001127705.1 alpha/beta hydrolase -
OXV10_RS22060 (4524544) 4524544..4524855 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
OXV10_RS22065 (4524852) 4524852..4525298 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
OXV10_RS22070 (4525313) 4525313..4526254 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV10_RS22075 (4526299) 4526299..4526736 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
OXV10_RS22080 (4526733) 4526733..4527605 - 873 WP_000921423.1 virulence factor BrkB family protein -
OXV10_RS22085 (4527599) 4527599..4528198 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T266004 WP_001159635.1 NZ_CP113540:c4523311-4523000 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT266004 WP_000362050.1 NZ_CP113540:c4522999-4522709 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References