Detailed information of TA system TA026600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2499322..2499839
• Replicon: chromosome
• Accession: NC_017337
• Organism: Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SAOV_RS12895
• Protein ID: WP_000375483.1
• Coordinates: 2499322..2499588 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: SAOV_RS12900
• Protein ID: WP_000584499.1
• Coordinates: 2499588..2499839 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOV_RS12870	2494473..2495009	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
SAOV_RS12875	2495529..2496353	-	825	WP_000594631.1	formate/nitrite transporter family protein	-
SAOV_RS12880	2496556..2496738	-	183	WP_000079140.1	hypothetical protein	-
SAOV_RS12885	2496825..2497292	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
SAOV_RS12890	2497478..2499028	-	1551	WP_000727763.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
SAOV_RS12895	2499322..2499588	-	267	WP_000375483.1	Txe/YoeB family addiction module toxin	Toxin
SAOV_RS12900	2499588..2499839	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SAOV_RS12905	2500003..2500103	-	101	Protein_2436	hypothetical protein	-
SAOV_RS12910	2500110..2500709	-	600	WP_000162810.1	DsbA family protein	-
SAOV_RS12915	2500728..2501090	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
SAOV_RS12920	2501345..2502595	+	1251	WP_001012239.1	FemA/FemB family glycyltransferase FmhA	-
SAOV_RS12925	2502688..2503419	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
SAOV_RS12930	2503416..2504135	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10450.05 Da
• Isoelectric Point: 10.2538

>T26600 WP_000375483.1 NC_017337:c2499588-2499322 [Staphylococcus aureus subsp. aureus ED133]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T26600 NC_017337:c2499588-2499322 [Staphylococcus aureus subsp. aureus ED133]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT26600 WP_000584499.1 NC_017337:c2499839-2499588 [Staphylococcus aureus subsp. aureus ED133]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT26600 NC_017337:c2499839-2499588 [Staphylococcus aureus subsp. aureus ED133]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: T1YB60