Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2499322..2499839 Replicon chromosome
Accession NC_017337
Organism Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SAOV_RS12895 Protein ID WP_000375483.1
Coordinates 2499322..2499588 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAOV_RS12900 Protein ID WP_000584499.1
Coordinates 2499588..2499839 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOV_RS12870 2494473..2495009 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SAOV_RS12875 2495529..2496353 - 825 WP_000594631.1 formate/nitrite transporter family protein -
SAOV_RS12880 2496556..2496738 - 183 WP_000079140.1 hypothetical protein -
SAOV_RS12885 2496825..2497292 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SAOV_RS12890 2497478..2499028 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAOV_RS12895 2499322..2499588 - 267 WP_000375483.1 Txe/YoeB family addiction module toxin Toxin
SAOV_RS12900 2499588..2499839 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAOV_RS12905 2500003..2500103 - 101 Protein_2436 hypothetical protein -
SAOV_RS12910 2500110..2500709 - 600 WP_000162810.1 DsbA family protein -
SAOV_RS12915 2500728..2501090 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAOV_RS12920 2501345..2502595 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
SAOV_RS12925 2502688..2503419 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAOV_RS12930 2503416..2504135 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.05 Da        Isoelectric Point: 10.2538

>T26600 WP_000375483.1 NC_017337:c2499588-2499322 [Staphylococcus aureus subsp. aureus ED133]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T26600 NC_017337:c2499588-2499322 [Staphylococcus aureus subsp. aureus ED133]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT26600 WP_000584499.1 NC_017337:c2499839-2499588 [Staphylococcus aureus subsp. aureus ED133]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT26600 NC_017337:c2499839-2499588 [Staphylococcus aureus subsp. aureus ED133]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References