Detailed information of TA system TA265992

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2478027..2478252
• Replicon: chromosome
• Accession: NZ_CP113540
• Organism: Salmonella enterica strain CYX

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: OXV10_RS12135
• Protein ID: WP_000813254.1
• Coordinates: 2478027..2478182 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2478194..2478252 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OXV10_RS12100	2473134..2473415	-	282	WP_000445513.1	phage holin family protein	-
OXV10_RS12105	2473405..2473593	-	189	WP_001688615.1	putative holin	-
OXV10_RS12110	2473587..2473910	-	324	Protein_2372	tellurite/colicin resistance protein	-
OXV10_RS12115	2476081..2476617	-	537	WP_000640113.1	DUF1133 family protein	-
OXV10_RS12120	2476614..2476904	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
OXV10_RS12125	2476904..2477503	-	600	WP_000940751.1	DUF1367 family protein	-
OXV10_RS12130	2477566..2477736	-	171	WP_000734094.1	hypothetical protein	-
OXV10_RS12135	2478027..2478182	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2478194..2478252	+	59	-	-	Antitoxin
OXV10_RS12140	2478609..2479541	+	933	WP_000556390.1	hypothetical protein	-
OXV10_RS12145	2479538..2480092	+	555	WP_001033796.1	hypothetical protein	-
OXV10_RS12150	2480254..2480583	-	330	WP_001676916.1	DUF977 family protein	-
OXV10_RS12155	2480627..2480674	-	48	Protein_2381	hypothetical protein	-
OXV10_RS12160	2480856..2481323	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
OXV10_RS12165	2481708..2481863	+	156	WP_085981757.1	DUF1391 family protein	-
OXV10_RS12170	2481971..2482492	-	522	WP_000004762.1	super-infection exclusion protein B	-
OXV10_RS12175	2482930..2483151	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2472592..2484463	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T265992 WP_000813254.1 NZ_CP113540:c2478182-2478027 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT265992 NZ_CP113540:2478194-2478252 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin