Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4529641..4530243 Replicon chromosome
Accession NZ_CP113539
Organism Salmonella enterica strain FFL

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag OXV09_RS21850 Protein ID WP_001159635.1
Coordinates 4529932..4530243 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV09_RS21845 Protein ID WP_000362050.1
Coordinates 4529641..4529931 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV09_RS21830 (4527134) 4527134..4528036 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OXV09_RS21835 (4528033) 4528033..4528668 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV09_RS21840 (4528665) 4528665..4529594 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OXV09_RS21845 (4529641) 4529641..4529931 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV09_RS21850 (4529932) 4529932..4530243 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OXV09_RS21855 (4530461) 4530461..4531390 + 930 WP_023255277.1 alpha/beta hydrolase -
OXV09_RS21860 (4531476) 4531476..4531787 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
OXV09_RS21865 (4531784) 4531784..4532230 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OXV09_RS21870 (4532245) 4532245..4533186 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV09_RS21875 (4533231) 4533231..4533668 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
OXV09_RS21880 (4533665) 4533665..4534537 - 873 WP_023255278.1 virulence factor BrkB family protein -
OXV09_RS21885 (4534531) 4534531..4535130 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T265984 WP_001159635.1 NZ_CP113539:c4530243-4529932 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT265984 WP_000362050.1 NZ_CP113539:c4529931-4529641 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References