Detailed information of TA system TA026598

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2236189..2236452
• Replicon: chromosome
• Accession: NC_017337
• Organism: Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: SAOV_RS11510
• Protein ID: WP_001802298.1
• Coordinates: 2236348..2236452 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2236189..2236353 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOV_RS11490	2232363..2233028	-	666	WP_001024100.1	SDR family oxidoreductase	-
SAOV_RS11495	2233180..2233500	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
SAOV_RS11500	2233502..2234482	+	981	WP_000019740.1	CDF family zinc efflux transporter CzrB	-
SAOV_RS11505	2234748..2235839	+	1092	WP_000495692.1	hypothetical protein	-
-	2236189..2236353	+	165	-	-	Antitoxin
SAOV_RS11510	2236348..2236452	-	105	WP_001802298.1	hypothetical protein	Toxin
SAOV_RS15365	2236613..2237096	-	484	Protein_2175	recombinase family protein	-
SAOV_RS15105	2237139..2238259	-	1121	Protein_2176	SAP domain-containing protein	-
SAOV_RS11530	2239300..2240157	-	858	WP_000370943.1	Cof-type HAD-IIB family hydrolase	-
SAOV_RS11535	2240225..2241007	-	783	WP_000909235.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T26598 WP_001802298.1 NC_017337:c2236452-2236348 [Staphylococcus aureus subsp. aureus ED133]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T26598 NC_017337:c2236452-2236348 [Staphylococcus aureus subsp. aureus ED133]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT26598 NC_017337:2236189-2236353 [Staphylococcus aureus subsp. aureus ED133]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin