265977

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2328839..2329361 Replicon chromosome
Accession NZ_CP113539
Organism Salmonella enterica strain FFL

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OXV09_RS11215 Protein ID WP_000221343.1
Coordinates 2329077..2329361 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OXV09_RS11210 Protein ID WP_000885424.1
Coordinates 2328839..2329087 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV09_RS11185 (2324932) 2324932..2326398 + 1467 WP_077946914.1 hypothetical protein -
OXV09_RS11190 (2326700) 2326700..2326990 + 291 WP_000742001.1 hypothetical protein -
OXV09_RS11195 (2327343) 2327343..2328069 + 727 Protein_2188 helix-turn-helix domain-containing protein -
OXV09_RS11200 (2328150) 2328150..2328482 - 333 WP_000253154.1 DUF1493 family protein -
OXV09_RS11205 (2328472) 2328472..2328687 - 216 WP_000206207.1 hypothetical protein -
OXV09_RS11210 (2328839) 2328839..2329087 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OXV09_RS11215 (2329077) 2329077..2329361 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXV09_RS11220 (2329532) 2329532..2329921 + 390 WP_000194089.1 RidA family protein -
OXV09_RS11225 (2329973) 2329973..2331052 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OXV09_RS11230 (2331245) 2331245..2331733 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
OXV09_RS11235 (2331778) 2331778..2333286 + 1509 WP_058214747.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2324935..2336143 11208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T265977 WP_000221343.1 NZ_CP113539:2329077-2329361 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT265977 WP_000885424.1 NZ_CP113539:2328839-2329087 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References