Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4653931..4654533 Replicon chromosome
Accession NZ_CP113538
Organism Salmonella enterica strain XSK

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag OXV06_RS22400 Protein ID WP_001159630.1
Coordinates 4654222..4654533 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV06_RS22395 Protein ID WP_000362050.1
Coordinates 4653931..4654221 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV06_RS22380 (4651424) 4651424..4652326 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OXV06_RS22385 (4652323) 4652323..4652958 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV06_RS22390 (4652955) 4652955..4653884 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OXV06_RS22395 (4653931) 4653931..4654221 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV06_RS22400 (4654222) 4654222..4654533 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OXV06_RS22405 (4654751) 4654751..4655680 + 930 WP_001127703.1 alpha/beta hydrolase -
OXV06_RS22410 (4655766) 4655766..4656077 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OXV06_RS22415 (4656074) 4656074..4656520 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OXV06_RS22420 (4656535) 4656535..4657476 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV06_RS22425 (4657521) 4657521..4657958 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
OXV06_RS22430 (4657955) 4657955..4658827 - 873 WP_000921427.1 virulence factor BrkB family protein -
OXV06_RS22435 (4658821) 4658821..4659420 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T265967 WP_001159630.1 NZ_CP113538:c4654533-4654222 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT265967 WP_000362050.1 NZ_CP113538:c4654221-4653931 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References