Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2384691..2385213 Replicon chromosome
Accession NZ_CP113538
Organism Salmonella enterica strain XSK

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OXV06_RS11460 Protein ID WP_000221343.1
Coordinates 2384929..2385213 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OXV06_RS11455 Protein ID WP_000885424.1
Coordinates 2384691..2384939 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV06_RS11430 (2379907) 2379907..2381373 + 1467 WP_000987828.1 hypothetical protein -
OXV06_RS11435 (2382181) 2382181..2382895 + 715 Protein_2235 helix-turn-helix domain-containing protein -
OXV06_RS11440 (2382951) 2382951..2383859 - 909 WP_010989018.1 hypothetical protein -
OXV06_RS11445 (2384002) 2384002..2384334 - 333 WP_198903240.1 DUF1493 family protein -
OXV06_RS11450 (2384324) 2384324..2384539 - 216 WP_000206207.1 hypothetical protein -
OXV06_RS11455 (2384691) 2384691..2384939 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OXV06_RS11460 (2384929) 2384929..2385213 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXV06_RS11465 (2385384) 2385384..2385773 + 390 WP_000194089.1 RidA family protein -
OXV06_RS11470 (2385825) 2385825..2386904 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OXV06_RS11475 (2387097) 2387097..2387585 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
OXV06_RS11480 (2387630) 2387630..2389138 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2379910..2391995 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T265960 WP_000221343.1 NZ_CP113538:2384929-2385213 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT265960 WP_000885424.1 NZ_CP113538:2384691-2384939 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References