Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4482771..4483373 Replicon chromosome
Accession NZ_CP113537
Organism Salmonella enterica strain YZY

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag OXV04_RS21370 Protein ID WP_023138876.1
Coordinates 4483062..4483373 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV04_RS21365 Protein ID WP_000362050.1
Coordinates 4482771..4483061 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV04_RS21350 (4480264) 4480264..4481166 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
OXV04_RS21355 (4481163) 4481163..4481798 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV04_RS21360 (4481795) 4481795..4482724 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OXV04_RS21365 (4482771) 4482771..4483061 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV04_RS21370 (4483062) 4483062..4483373 - 312 WP_023138876.1 hypothetical protein Toxin
OXV04_RS21375 (4483591) 4483591..4484520 + 930 WP_126524392.1 alpha/beta hydrolase -
OXV04_RS21380 (4484606) 4484606..4484917 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
OXV04_RS21385 (4484914) 4484914..4485360 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
OXV04_RS21390 (4485375) 4485375..4486316 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV04_RS21395 (4486361) 4486361..4486798 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
OXV04_RS21400 (4486795) 4486795..4487667 - 873 WP_000921423.1 virulence factor BrkB family protein -
OXV04_RS21405 (4487661) 4487661..4488260 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T265948 WP_023138876.1 NZ_CP113537:c4483373-4483062 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT265948 WP_000362050.1 NZ_CP113537:c4483061-4482771 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References