Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4658421..4659023 Replicon chromosome
Accession NZ_CP113536
Organism Salmonella enterica strain ZCX

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag OXV07_RS22605 Protein ID WP_001159630.1
Coordinates 4658712..4659023 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV07_RS22600 Protein ID WP_000362050.1
Coordinates 4658421..4658711 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV07_RS22585 (4655914) 4655914..4656816 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OXV07_RS22590 (4656813) 4656813..4657448 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV07_RS22595 (4657445) 4657445..4658374 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OXV07_RS22600 (4658421) 4658421..4658711 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV07_RS22605 (4658712) 4658712..4659023 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OXV07_RS22610 (4659241) 4659241..4660170 + 930 WP_001127703.1 alpha/beta hydrolase -
OXV07_RS22615 (4660256) 4660256..4660567 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OXV07_RS22620 (4660564) 4660564..4661010 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OXV07_RS22625 (4661025) 4661025..4661966 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV07_RS22630 (4662011) 4662011..4662448 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
OXV07_RS22635 (4662445) 4662445..4663317 - 873 WP_000921427.1 virulence factor BrkB family protein -
OXV07_RS22640 (4663311) 4663311..4663910 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T265933 WP_001159630.1 NZ_CP113536:c4659023-4658712 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT265933 WP_000362050.1 NZ_CP113536:c4658711-4658421 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References