Detailed information of TA system TA026592

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1145099..1145411
• Replicon: chromosome
• Accession: NC_017337
• Organism: Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: SAOV_RS14875
• Protein ID: WP_078061146.1
• Coordinates: 1145099..1145275 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1145332..1145411 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOV_RS05790	1142715..1142867	+	153	WP_001153680.1	hypothetical protein	-
SAOV_RS05795	1142914..1143201	+	288	WP_001040261.1	hypothetical protein	-
SAOV_RS14530	1143296..1143664	+	369	WP_135831022.1	hypothetical protein	-
SAOV_RS05800	1144119..1144898	+	780	WP_000746437.1	exotoxin	-
SAOV_RS14875	1145099..1145275	+	177	WP_078061146.1	putative holin-like toxin	Toxin
-	1145332..1145411	-	80	-	-	Antitoxin
SAOV_RS05810	1145478..1145915	+	438	WP_000354124.1	phage holin	-
SAOV_RS05815	1145896..1146504	+	609	Protein_1120	CHAP domain-containing protein	-
SAOV_RS05820	1146567..1147112	+	546	WP_000136401.1	NUMOD4 motif-containing HNH endonuclease	-
SAOV_RS05825	1147436..1148275	+	840	Protein_1122	SH3 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea	1107930..1148275	40345

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6848.50 Da
• Isoelectric Point: 10.6777

>T26592 WP_078061146.1 NC_017337:1145099-1145275 [Staphylococcus aureus subsp. aureus ED133]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Nucleotide

• Length: 177 bp

>T26592 NC_017337:1145099-1145275 [Staphylococcus aureus subsp. aureus ED133]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCGCTAATTGGTCTAGTAATCAAGCTTATTGAAT
TAAGCATTAAAAAATAA

Antitoxin

Nucleotide

• Length: 80 bp

>AT26592 NC_017337:c1145411-1145332 [Staphylococcus aureus subsp. aureus ED133]
GATGTGTTAATTTATATATAGAAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTA

Structures

Antitoxin