Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4775289..4775891 Replicon chromosome
Accession NZ_CP113535
Organism Salmonella enterica strain ZLQ

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag OXV11_RS23470 Protein ID WP_001159630.1
Coordinates 4775580..4775891 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV11_RS23465 Protein ID WP_000362050.1
Coordinates 4775289..4775579 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV11_RS23450 (4772782) 4772782..4773684 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OXV11_RS23455 (4773681) 4773681..4774316 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV11_RS23460 (4774313) 4774313..4775242 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OXV11_RS23465 (4775289) 4775289..4775579 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV11_RS23470 (4775580) 4775580..4775891 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OXV11_RS23475 (4776109) 4776109..4777038 + 930 WP_001127703.1 alpha/beta hydrolase -
OXV11_RS23480 (4777124) 4777124..4777435 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OXV11_RS23485 (4777432) 4777432..4777878 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OXV11_RS23490 (4777893) 4777893..4778834 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV11_RS23495 (4778879) 4778879..4779316 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
OXV11_RS23500 (4779313) 4779313..4780185 - 873 WP_000921427.1 virulence factor BrkB family protein -
OXV11_RS23505 (4780179) 4780179..4780778 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T265914 WP_001159630.1 NZ_CP113535:c4775891-4775580 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT265914 WP_000362050.1 NZ_CP113535:c4775579-4775289 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References