265907

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2484904..2485426 Replicon chromosome
Accession NZ_CP113535
Organism Salmonella enterica strain ZLQ

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OXV11_RS12215 Protein ID WP_000221343.1
Coordinates 2485142..2485426 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OXV11_RS12210 Protein ID WP_000885424.1
Coordinates 2484904..2485152 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV11_RS12185 (2480120) 2480120..2481586 + 1467 WP_000987828.1 hypothetical protein -
OXV11_RS12190 (2482394) 2482394..2483108 + 715 Protein_2386 helix-turn-helix domain-containing protein -
OXV11_RS12195 (2483164) 2483164..2484072 - 909 WP_010989018.1 hypothetical protein -
OXV11_RS12200 (2484215) 2484215..2484547 - 333 WP_000253154.1 DUF1493 family protein -
OXV11_RS12205 (2484537) 2484537..2484752 - 216 WP_000206207.1 hypothetical protein -
OXV11_RS12210 (2484904) 2484904..2485152 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OXV11_RS12215 (2485142) 2485142..2485426 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXV11_RS12220 (2485597) 2485597..2485986 + 390 WP_000194089.1 RidA family protein -
OXV11_RS12225 (2486038) 2486038..2487117 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OXV11_RS12230 (2487310) 2487310..2487798 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
OXV11_RS12235 (2487843) 2487843..2489351 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2480123..2492208 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T265907 WP_000221343.1 NZ_CP113535:2485142-2485426 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT265907 WP_000885424.1 NZ_CP113535:2484904-2485152 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References