Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4517586..4518188 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag OXV08_RS21800 Protein ID WP_001159635.1
Coordinates 4517877..4518188 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXV08_RS21795 Protein ID WP_000362050.1
Coordinates 4517586..4517876 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS21780 (4515079) 4515079..4515981 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OXV08_RS21785 (4515978) 4515978..4516613 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OXV08_RS21790 (4516610) 4516610..4517539 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
OXV08_RS21795 (4517586) 4517586..4517876 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OXV08_RS21800 (4517877) 4517877..4518188 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
OXV08_RS21805 (4518406) 4518406..4519335 + 930 WP_001127705.1 alpha/beta hydrolase -
OXV08_RS21810 (4519421) 4519421..4519732 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
OXV08_RS21815 (4519729) 4519729..4520175 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OXV08_RS21820 (4520190) 4520190..4521131 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OXV08_RS21825 (4521176) 4521176..4521613 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
OXV08_RS21830 (4521610) 4521610..4522482 - 873 WP_000921423.1 virulence factor BrkB family protein -
OXV08_RS21835 (4522476) 4522476..4523075 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T265895 WP_001159635.1 NZ_CP113534:c4518188-4517877 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT265895 WP_000362050.1 NZ_CP113534:c4517876-4517586 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References