Detailed information of TA system TA026588

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 364574..365082
• Replicon: chromosome
• Accession: NC_017337
• Organism: Staphylococcus aureus subsp. aureus ED133

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: SAOV_RS01750
• Protein ID: WP_000448764.1
• Coordinates: 364780..365082 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	364574..364684 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOV_RS01715	359668..359958	+	291	WP_000179860.1	hypothetical protein	-
SAOV_RS01720	359974..361884	+	1911	WP_000429563.1	hypothetical protein	-
SAOV_RS01725	361884..363350	+	1467	WP_000067157.1	BppU family phage baseplate upper protein	-
SAOV_RS01730	363350..363739	+	390	WP_001166604.1	DUF2977 domain-containing protein	-
SAOV_RS01735	363732..363896	+	165	WP_000916020.1	XkdX family protein	-
SAOV_RS01740	363942..364241	+	300	WP_000466773.1	DUF2951 family protein	-
SAOV_RS15420	364393..364582	+	190	Protein_336	putative holin-like toxin	-
-	364574..364684	-	111	NuclAT_0	-	Antitoxin
-	364574..364684	-	111	NuclAT_0	-	Antitoxin
-	364574..364684	-	111	NuclAT_0	-	Antitoxin
-	364574..364684	-	111	NuclAT_0	-	Antitoxin
SAOV_RS15280	364629..364729	-	101	Protein_337	hypothetical protein	-
SAOV_RS01750	364780..365082	+	303	WP_000448764.1	phage holin	Toxin
SAOV_RS01755	365094..366548	+	1455	WP_000930278.1	N-acetylmuramoyl-L-alanine amidase	-
SAOV_RS01760	368062..368559	+	498	WP_001803960.1	hypothetical protein	-
SAOV_RS01765	369119..369946	-	828	WP_000136028.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	321155..366548	45393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11230.99 Da
• Isoelectric Point: 9.6587

>T26588 WP_000448764.1 NC_017337:364780-365082 [Staphylococcus aureus subsp. aureus ED133]
METKVITRYIVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTAYKDNPTSQEGRWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T26588 NC_017337:364780-365082 [Staphylococcus aureus subsp. aureus ED133]
ATGGAAACAAAAGTAATAACAAGATATATTGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAACAAAGGTATAAG
CCCGATACCAGTAGATGAAGAGAGTATTTCATCGATTATCTTAACAGTCATTGCTTTATACACCGCTTATAAAGACAATC
CAACATCACAAGAAGGACGCTGGGCGAATCAAAAACTAAAGAAATATAAAGCTGAAAATAAGTATAGAAAAGCAACAGGA
CAAGCGCCAATTAAAGAAGTAATGACACCTACAAATATGAATGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 111 bp

>AT26588 NC_017337:c364684-364574 [Staphylococcus aureus subsp. aureus ED133]
AAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTGTAGTTAAATGAATTTATATAATCCTCTAACCATCG
TACTCGTCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin