Detailed information of TA system TA026586

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2563849..2564033
• Replicon: chromosome
• Accession: NC_017333
• Organism: Staphylococcus aureus subsp. aureus ST398

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: SAPIG_RS13060
• Protein ID: WP_000482647.1
• Coordinates: 2563926..2564033 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2563849..2563909 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAPIG_RS13035	2559303..2559470	-	168	WP_001798790.1	hypothetical protein	-
SAPIG_RS13045	2559701..2561434	-	1734	WP_000486511.1	ABC transporter ATP-binding protein/permease	-
SAPIG_RS13050	2561459..2563222	-	1764	WP_001064818.1	ABC transporter ATP-binding protein/permease	-
-	2563849..2563909	+	61	-	-	Antitoxin
SAPIG_RS13060	2563926..2564033	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
SAPIG_RS13065	2564167..2564553	-	387	WP_000779355.1	flippase GtxA	-
SAPIG_RS13070	2564820..2565962	+	1143	WP_001176859.1	glycerate kinase	-
SAPIG_RS13075	2566022..2566681	+	660	WP_000831300.1	hypothetical protein	-
SAPIG_RS13080	2566869..2568080	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
SAPIG_RS13085	2568203..2568676	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T26586 WP_000482647.1 NC_017333:c2564033-2563926 [Staphylococcus aureus subsp. aureus ST398]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T26586 NC_017333:c2564033-2563926 [Staphylococcus aureus subsp. aureus ST398]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT26586 NC_017333:2563849-2563909 [Staphylococcus aureus subsp. aureus ST398]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin