Detailed information of TA system TA026584

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2268019..2268282
• Replicon: chromosome
• Accession: NC_017333
• Organism: Staphylococcus aureus subsp. aureus ST398

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: SAPIG_RS11490
• Protein ID: WP_001802298.1
• Coordinates: 2268178..2268282 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2268019..2268183 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAPIG_RS11470	2264204..2264869	-	666	WP_001024099.1	SDR family oxidoreductase	-
SAPIG_RS11475	2265021..2265341	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
SAPIG_RS11480	2265343..2266323	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
SAPIG_RS11485	2266589..2267680	+	1092	WP_000495673.1	hypothetical protein	-
-	2268019..2268183	+	165	-	-	Antitoxin
SAPIG_RS11490	2268178..2268282	-	105	WP_001802298.1	hypothetical protein	Toxin
SAPIG_RS15280	2268962..2269120	+	159	WP_001792784.1	hypothetical protein	-
SAPIG_RS11495	2269556..2269648	+	93	WP_000220902.1	hypothetical protein	-
SAPIG_RS11500	2269778..2270635	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
SAPIG_RS11505	2270703..2271485	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
SAPIG_RS11510	2271775..2272383	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T26584 WP_001802298.1 NC_017333:c2268282-2268178 [Staphylococcus aureus subsp. aureus ST398]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T26584 NC_017333:c2268282-2268178 [Staphylococcus aureus subsp. aureus ST398]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT26584 NC_017333:2268019-2268183 [Staphylococcus aureus subsp. aureus ST398]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin