Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4953287..4953889 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag OWO50_RS23705 Protein ID WP_000897305.1
Coordinates 4953578..4953889 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OWO50_RS23700 Protein ID WP_000356397.1
Coordinates 4953287..4953577 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS23680 (4949789) 4949789..4950691 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
OWO50_RS23685 (4950688) 4950688..4951323 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
OWO50_RS23690 (4951320) 4951320..4952249 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
OWO50_RS23695 (4952464) 4952464..4952682 - 219 WP_001298592.1 CopG family transcriptional regulator -
OWO50_RS23700 (4953287) 4953287..4953577 - 291 WP_000356397.1 NadS family protein Antitoxin
OWO50_RS23705 (4953578) 4953578..4953889 - 312 WP_000897305.1 hypothetical protein Toxin
OWO50_RS23710 (4954118) 4954118..4955026 + 909 WP_001298596.1 alpha/beta hydrolase -
OWO50_RS23715 (4955090) 4955090..4956031 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
OWO50_RS23720 (4956076) 4956076..4956513 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
OWO50_RS23725 (4956510) 4956510..4957382 - 873 WP_000920762.1 virulence factor BrkB family protein -
OWO50_RS23730 (4957376) 4957376..4957975 - 600 WP_001298594.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12172.16 Da        Isoelectric Point: 9.7791

>T265839 WP_000897305.1 NZ_CP113503:c4953889-4953578 [Escherichia coli]
ILFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT265839 WP_000356397.1 NZ_CP113503:c4953577-4953287 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References