Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4274554..4274966 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag OWO50_RS20545 Protein ID WP_000132614.1
Coordinates 4274625..4274966 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4274554..4274630 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS20535 (4271229) 4271229..4272698 + 1470 WP_001540814.1 type I restriction-modification system subunit M -
OWO50_RS20540 (4272698) 4272698..4274404 + 1707 WP_001100194.1 restriction endonuclease subunit S -
- (4274554) 4274554..4274630 - 77 NuclAT_6 - Antitoxin
- (4274554) 4274554..4274630 - 77 NuclAT_6 - Antitoxin
- (4274554) 4274554..4274630 - 77 NuclAT_6 - Antitoxin
- (4274554) 4274554..4274630 - 77 NuclAT_6 - Antitoxin
- (4274554) 4274554..4274630 - 77 NuclAT_7 - Antitoxin
- (4274554) 4274554..4274630 - 77 NuclAT_7 - Antitoxin
- (4274554) 4274554..4274630 - 77 NuclAT_7 - Antitoxin
- (4274554) 4274554..4274630 - 77 NuclAT_7 - Antitoxin
OWO50_RS20545 (4274625) 4274625..4274966 + 342 WP_000132614.1 endoribonuclease SymE Toxin
OWO50_RS20550 (4275013) 4275013..4276176 - 1164 WP_072002093.1 DUF1524 domain-containing protein -
OWO50_RS20555 (4276224) 4276224..4277106 - 883 Protein_4034 DUF262 domain-containing protein -
OWO50_RS20560 (4277296) 4277296..4277373 + 78 Protein_4035 hypothetical protein -
OWO50_RS20565 (4277512) 4277512..4278432 - 921 WP_000181195.1 Rpn family recombination-promoting nuclease/putative transposase -
OWO50_RS20570 (4278617) 4278617..4279897 + 1281 WP_001298033.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4258434..4277169 18735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T265832 WP_000132614.1 NZ_CP113503:4274625-4274966 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT265832 NZ_CP113503:c4274630-4274554 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References