Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2609522..2610084 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag OWO50_RS12355 Protein ID WP_000605675.1
Coordinates 2609522..2609800 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag OWO50_RS12360 Protein ID WP_000781370.1
Coordinates 2609800..2610084 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS12330 (2605108) 2605108..2605539 - 432 WP_000152305.1 peroxiredoxin OsmC -
OWO50_RS12335 (2605884) 2605884..2606099 + 216 WP_000495766.1 biofilm-dependent modulation protein -
OWO50_RS12340 (2606201) 2606201..2606338 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
OWO50_RS12345 (2606495) 2606495..2608192 + 1698 WP_000433462.1 malate dehydrogenase -
OWO50_RS12350 (2608326) 2608326..2609336 + 1011 WP_000642380.1 alcohol dehydrogenase AdhP -
OWO50_RS12355 (2609522) 2609522..2609800 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OWO50_RS12360 (2609800) 2609800..2610084 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
OWO50_RS12365 (2610313) 2610313..2610966 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
OWO50_RS12370 (2610959) 2610959..2611843 - 885 WP_001240581.1 formate dehydrogenase N subunit beta -
OWO50_RS12375 (2611856) 2611856..2614903 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T265825 WP_000605675.1 NZ_CP113503:2609522-2609800 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT265825 WP_000781370.1 NZ_CP113503:2609800-2610084 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References