Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1968916..1969418 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag OWO50_RS09240 Protein ID WP_000767822.1
Coordinates 1969164..1969418 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag OWO50_RS09235 Protein ID WP_001259255.1
Coordinates 1968916..1969167 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS09210 (1964094) 1964094..1965161 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
OWO50_RS09215 (1965161) 1965161..1966231 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
OWO50_RS09220 (1966228) 1966228..1967532 - 1305 WP_001297912.1 histidinol dehydrogenase -
OWO50_RS09225 (1967538) 1967538..1968437 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
OWO50_RS09230 (1968583) 1968583..1968633 - 51 WP_001364200.1 his operon leader peptide -
OWO50_RS09235 (1968916) 1968916..1969167 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
OWO50_RS09240 (1969164) 1969164..1969418 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
OWO50_RS09245 (1969501) 1969501..1970325 + 825 WP_000754733.1 SDR family oxidoreductase -
OWO50_RS09250 (1970371) 1970371..1971300 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
OWO50_RS09255 (1971515) 1971515..1971577 + 63 WP_010723108.1 membrane protein YoeI -
OWO50_RS09260 (1971567) 1971567..1972925 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T265818 WP_000767822.1 NZ_CP113503:1969164-1969418 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT265818 WP_001259255.1 NZ_CP113503:1968916-1969167 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References