Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 653018..653817 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag OWO50_RS03210 Protein ID WP_000347252.1
Coordinates 653018..653482 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag OWO50_RS03215 Protein ID WP_001296435.1
Coordinates 653482..653817 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS03180 (648019) 648019..648453 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
OWO50_RS03185 (648471) 648471..649349 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
OWO50_RS03190 (649339) 649339..650118 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
OWO50_RS03195 (650129) 650129..650602 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
OWO50_RS03200 (650625) 650625..651905 - 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
OWO50_RS03205 (652154) 652154..652963 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OWO50_RS03210 (653018) 653018..653482 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OWO50_RS03215 (653482) 653482..653817 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OWO50_RS03220 (653966) 653966..655537 - 1572 WP_001273939.1 galactarate dehydratase -
OWO50_RS03225 (655912) 655912..657246 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
OWO50_RS03230 (657262) 657262..658032 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T265814 WP_000347252.1 NZ_CP113503:c653482-653018 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT265814 WP_001296435.1 NZ_CP113503:c653817-653482 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References