Detailed information of TA system TA026578

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1639161..1639740
• Replicon: chromosome
• Accession: NC_017333
• Organism: Staphylococcus aureus subsp. aureus ST398

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAPIG_RS08080
• Protein ID: WP_001025401.1
• Coordinates: 1639495..1639740 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1639161..1639526 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAPIG_RS08040	1635905..1636462	-	558	WP_000645042.1	DUF2815 family protein	-
SAPIG_RS08045	1636488..1637654	-	1167	WP_000762524.1	DUF2800 domain-containing protein	-
SAPIG_RS08050	1637651..1638013	-	363	WP_000985976.1	hypothetical protein	-
SAPIG_RS08055	1638028..1638351	-	324	WP_000174994.1	hypothetical protein	-
SAPIG_RS08060	1638430..1638591	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAPIG_RS08065	1638604..1638867	-	264	WP_001124158.1	helix-turn-helix domain-containing protein	-
SAPIG_RS08070	1638892..1639106	-	215	Protein_1554	hypothetical protein	-
SAPIG_RS08075	1639161..1639526	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAPIG_RS08080	1639495..1639740	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAPIG_RS08085	1639796..1640005	+	210	WP_000642492.1	hypothetical protein	-
SAPIG_RS08090	1639995..1640138	-	144	WP_000939498.1	hypothetical protein	-
SAPIG_RS08095	1640153..1640596	-	444	WP_000435360.1	hypothetical protein	-
SAPIG_RS08100	1640644..1640856	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
SAPIG_RS08105	1641008..1641739	+	732	WP_000511091.1	XRE family transcriptional regulator	-
SAPIG_RS08110	1641810..1641992	+	183	WP_000705240.1	hypothetical protein	-
SAPIG_RS08115	1641989..1643185	+	1197	WP_000173647.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1590852..1660816	69964

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T26578 WP_001025401.1 NC_017333:c1639740-1639495 [Staphylococcus aureus subsp. aureus ST398]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T26578 NC_017333:c1639740-1639495 [Staphylococcus aureus subsp. aureus ST398]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT26578 NC_017333:1639161-1639526 [Staphylococcus aureus subsp. aureus ST398]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin