Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2153304..2154103 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag FG550_RS10405 Protein ID WP_000347270.1
Coordinates 2153639..2154103 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag FG550_RS10400 Protein ID WP_001551693.1
Coordinates 2153304..2153639 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS10385 (2149089) 2149089..2149859 - 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -
FG550_RS10390 (2149875) 2149875..2151209 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
FG550_RS10395 (2151584) 2151584..2153155 + 1572 WP_001273738.1 galactarate dehydratase -
FG550_RS10400 (2153304) 2153304..2153639 + 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
FG550_RS10405 (2153639) 2153639..2154103 + 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
FG550_RS10410 (2154158) 2154158..2154967 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
FG550_RS10415 (2155216) 2155216..2156496 + 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
FG550_RS10420 (2156519) 2156519..2156992 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
FG550_RS10425 (2157003) 2157003..2157790 + 788 Protein_2046 PTS N-acetylgalactosamine transporter subunit IIC -
FG550_RS10430 (2157780) 2157780..2158658 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2144542..2154103 9561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T265752 WP_000347270.1 NZ_CP113486:2153639-2154103 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT265752 WP_001551693.1 NZ_CP113486:2153304-2153639 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References