265738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3945146..3945855 Replicon chromosome
Accession NZ_CP113485
Organism Mycobacterium avium subsp. paratuberculosis strain LN20

Toxin (Protein)


Gene name HigB2 Uniprot ID X7V9P5
Locus tag OUZ54_RS18715 Protein ID WP_003873387.1
Coordinates 3945146..3945550 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID Q73S10
Locus tag OUZ54_RS18720 Protein ID WP_003873388.1
Coordinates 3945547..3945855 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUZ54_RS18700 (OUZ54_18700) 3941399..3942574 + 1176 WP_003874378.1 trehalose-phosphatase -
OUZ54_RS18705 (OUZ54_18705) 3942571..3943437 - 867 WP_003874377.1 MaoC family dehydratase -
OUZ54_RS18710 (OUZ54_18710) 3943659..3944879 + 1221 WP_010948702.1 IS110 family transposase -
OUZ54_RS18715 (OUZ54_18715) 3945146..3945550 + 405 WP_003873387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OUZ54_RS18720 (OUZ54_18720) 3945547..3945855 + 309 WP_003873388.1 helix-turn-helix transcriptional regulator Antitoxin
OUZ54_RS18725 (OUZ54_18725) 3946342..3947868 - 1527 WP_003879517.1 adenylate/guanylate cyclase domain-containing protein -
OUZ54_RS18730 (OUZ54_18730) 3947963..3949579 - 1617 WP_003873390.1 chaperonin GroEL -
OUZ54_RS18735 (OUZ54_18735) 3949668..3949970 - 303 WP_003873391.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3943680..3944879 1199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(31-91)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15503.82 Da        Isoelectric Point: 10.3815

>T265738 WP_003873387.1 NZ_CP113485:3945146-3945550 [Mycobacterium avium subsp. paratuberculosis]
VRKWEVDLTLIEAWMDALDDEEYDNLIAALEQLEEHGPITRRPFVDTLEGSRHPNMKELRPRPTKAGAHIRVLFAFDTRS
RAIMLIAGDKAGNWSKWYAKHIPIADELFDAHQKRLHKAAAKATNRKPRKGKKR

Download         Length: 405 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11445.94 Da        Isoelectric Point: 10.0801

>AT265738 WP_003873388.1 NZ_CP113485:3945547-3945855 [Mycobacterium avium subsp. paratuberculosis]
MTNLDDMRRRRPGNRTRIDAIKAEMDREVAQYRLRELREAAGYTQTTLAAAIGVGQNRVSQMEHGDLGTSRVDTLRKYVE
ATGGELEVSVKRPDGSRVLLSL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X7V9P5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4U5M0

References