Detailed information of TA system TA026573

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 375772..376351
• Replicon: chromosome
• Accession: NC_017333
• Organism: Staphylococcus aureus subsp. aureus ST398

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAPIG_RS01710
• Protein ID: WP_001025401.1
• Coordinates: 375772..376017 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	375986..376351 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAPIG_RS01665	371791..372405	+	615	WP_000191464.1	hypothetical protein	-
SAPIG_RS01670	372402..372548	-	147	WP_001795334.1	hypothetical protein	-
SAPIG_RS01675	372778..373362	-	585	WP_000825948.1	hypothetical protein	-
SAPIG_RS01680	373380..373841	-	462	WP_000525004.1	hypothetical protein	-
SAPIG_RS01685	373854..374168	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SAPIG_RS01690	374320..374556	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SAPIG_RS01695	374570..375346	+	777	WP_001148544.1	Rha family transcriptional regulator	-
SAPIG_RS01700	375374..375517	+	144	WP_000939498.1	hypothetical protein	-
SAPIG_RS01705	375507..375716	-	210	WP_000642492.1	hypothetical protein	-
SAPIG_RS01710	375772..376017	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAPIG_RS01715	375986..376351	-	366	WP_001128433.1	hypothetical protein	Antitoxin
SAPIG_RS01720	376406..376620	+	215	Protein_338	hypothetical protein	-
SAPIG_RS01725	376645..376908	+	264	WP_001124158.1	helix-turn-helix domain-containing protein	-
SAPIG_RS01730	376921..377082	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAPIG_RS01735	377161..377484	+	324	WP_000174994.1	hypothetical protein	-
SAPIG_RS01740	377499..377861	+	363	WP_000985976.1	hypothetical protein	-
SAPIG_RS01745	377858..379024	+	1167	WP_000762523.1	DUF2800 domain-containing protein	-
SAPIG_RS01750	379050..379607	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	370475..417309	46834

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T26573 WP_001025401.1 NC_017333:375772-376017 [Staphylococcus aureus subsp. aureus ST398]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T26573 NC_017333:375772-376017 [Staphylococcus aureus subsp. aureus ST398]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT26573 NC_017333:c376351-375986 [Staphylococcus aureus subsp. aureus ST398]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin