Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3261241..3261862 Replicon chromosome
Accession NZ_CP113438
Organism Legionella pneumophila strain PATHC003

Toxin (Protein)


Gene name higB Uniprot ID Q5ZRG7
Locus tag OXA91_RS14525 Protein ID WP_010948600.1
Coordinates 3261641..3261862 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXA91_RS14520 Protein ID WP_010948599.1
Coordinates 3261241..3261531 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA91_RS14505 (OXA91_14505) 3257302..3258789 + 1488 WP_010948597.1 lpg2912 family Dot/Icm T4SS effector -
OXA91_RS14510 (OXA91_14510) 3258951..3260393 - 1443 WP_010948598.1 ATP-binding protein -
OXA91_RS14515 (OXA91_14515) 3260761..3260952 + 192 WP_014327021.1 hypothetical protein -
OXA91_RS14520 (OXA91_14520) 3261241..3261531 - 291 WP_010948599.1 helix-turn-helix domain-containing protein Antitoxin
OXA91_RS14525 (OXA91_14525) 3261641..3261862 - 222 WP_010948600.1 hypothetical protein Toxin
OXA91_RS14530 (OXA91_14530) 3262067..3262570 - 504 WP_015443887.1 hypothetical protein -
OXA91_RS14535 (OXA91_14535) 3262680..3263726 - 1047 WP_010948602.1 FAD-dependent oxidoreductase -
OXA91_RS14540 (OXA91_14540) 3264030..3264992 - 963 WP_015443886.1 lytic murein transglycosylase -
OXA91_RS14545 (OXA91_14545) 3265522..3266700 + 1179 WP_010948604.1 serine hydrolase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8288.46 Da        Isoelectric Point: 3.7468

>T265722 WP_010948600.1 NZ_CP113438:c3261862-3261641 [Legionella pneumophila]
MIFIETPIFTEDVKELLSDEEYAEFQEYLADNPLAGDVIQQTGKLANWQTAKSSMVISRQMGSEAVLELFIIM

Download         Length: 222 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.68 Da        Isoelectric Point: 8.0670

>AT265722 WP_010948599.1 NZ_CP113438:c3261531-3261241 [Legionella pneumophila]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVSIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAG

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5ZRG7

Antitoxin

Source ID Structure

References