265721

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2635647..2636890 Replicon chromosome
Accession NZ_CP113438
Organism Legionella pneumophila strain PATHC003

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag OXA91_RS11705 Protein ID WP_010948074.1
Coordinates 2635952..2636890 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag OXA91_RS11700 Protein ID WP_010948073.1
Coordinates 2635647..2635955 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA91_RS11670 (OXA91_11670) 2631083..2631448 + 366 WP_010948069.1 BRCT domain-containing protein -
OXA91_RS11675 (OXA91_11675) 2631805..2632170 - 366 WP_010948070.1 TraK family protein -
OXA91_RS11680 (OXA91_11680) 2632355..2632495 - 141 WP_153802426.1 hypothetical protein -
OXA91_RS11685 (OXA91_11685) 2632498..2634249 - 1752 WP_010948071.1 DUF927 domain-containing protein -
OXA91_RS11690 (OXA91_11690) 2634315..2634590 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
OXA91_RS11695 (OXA91_11695) 2635423..2635650 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
OXA91_RS11700 (OXA91_11700) 2635647..2635955 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
OXA91_RS11705 (OXA91_11705) 2635952..2636890 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
OXA91_RS11710 (OXA91_11710) 2637433..2638047 + 615 WP_010948075.1 hypothetical protein -
OXA91_RS11715 (OXA91_11715) 2638203..2638409 - 207 WP_015444115.1 hypothetical protein -
OXA91_RS11720 (OXA91_11720) 2638746..2640014 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
OXA91_RS11725 (OXA91_11725) 2640484..2640774 - 291 WP_223804318.1 hypothetical protein -
OXA91_RS11730 (OXA91_11730) 2640755..2641420 - 666 WP_015444114.1 hypothetical protein -
OXA91_RS11735 (OXA91_11735) 2641596..2641727 - 132 WP_015444112.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2629669..2630844 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T265721 WP_010948074.1 NZ_CP113438:2635952-2636890 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT265721 WP_010948073.1 NZ_CP113438:2635647-2635955 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
PDB 7VKB
AlphaFold DB Q5ZSZ7

References