Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_31
Location 74432..75036 Replicon chromosome
Accession NZ_CP113437
Organism Legionella pneumophila strain PATHC007

Toxin (Protein)


Gene name higB Uniprot ID A0A128WF47
Locus tag OXA90_RS00370 Protein ID WP_011212715.1
Coordinates 74432..74755 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXA90_RS00375 Protein ID WP_011212716.1
Coordinates 74752..75036 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA90_RS00345 (OXA90_00345) 69792..70637 - 846 WP_011212710.1 hypothetical protein -
OXA90_RS00350 (OXA90_00350) 70966..71220 - 255 WP_041173947.1 hypothetical protein -
OXA90_RS00355 (OXA90_00355) 71758..72699 + 942 WP_011212712.1 hypothetical protein -
OXA90_RS00360 (OXA90_00360) 72714..72902 + 189 WP_224750877.1 transposase -
OXA90_RS00365 (OXA90_00365) 73128..74348 + 1221 WP_011212714.1 site-specific integrase -
OXA90_RS00370 (OXA90_00370) 74432..74755 + 324 WP_011212715.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OXA90_RS00375 (OXA90_00375) 74752..75036 + 285 WP_011212716.1 helix-turn-helix transcriptional regulator Antitoxin
OXA90_RS00380 (OXA90_00380) 75230..76051 + 822 WP_224750878.1 hypothetical protein -
OXA90_RS00385 (OXA90_00385) 76357..76755 + 399 WP_011212718.1 DUF1780 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12144.36 Da        Isoelectric Point: 9.7878

>T265719 WP_011212715.1 NZ_CP113437:74432-74755 [Legionella pneumophila]
MSWIVEFYNESVEEAILTMPPKIQARMIKLLELIETHGANLGPPHTEAMGDGLFEIRAKAQEGIGRSLYCYMKGKHIVVL
HAFVKKSAKTPKPDLQLALKRKREVEK

Download         Length: 324 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.22 Da        Isoelectric Point: 9.8787

>AT265719 WP_011212716.1 NZ_CP113437:74752-75036 [Legionella pneumophila]
MMKLKTLKAKALKNPEVKEAYDALESEFALIDALLTMRQKAGLTQEELAERMGTKKGNISRLEKGNTNPSWNTLEKYAHA
CGFDISMAVKRIAS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A128WF47

Antitoxin

Source ID Structure

References