Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3234232..3234869 Replicon chromosome
Accession NZ_CP113436
Organism Legionella pneumophila strain PATHC021

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OXA88_RS14375 Protein ID WP_268169339.1
Coordinates 3234525..3234869 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXA88_RS14370 Protein ID WP_010948599.1
Coordinates 3234232..3234522 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA88_RS14350 (OXA88_14350) 3230293..3231780 + 1488 WP_010948597.1 lpg2912 family Dot/Icm T4SS effector -
OXA88_RS14355 (OXA88_14355) 3231942..3233384 - 1443 WP_010948598.1 ATP-binding protein -
OXA88_RS14360 (OXA88_14360) 3233566..3233715 - 150 WP_154074588.1 hypothetical protein -
OXA88_RS14365 (OXA88_14365) 3233752..3233943 + 192 WP_014327021.1 hypothetical protein -
OXA88_RS14370 (OXA88_14370) 3234232..3234522 - 291 WP_010948599.1 helix-turn-helix domain-containing protein Antitoxin
OXA88_RS14375 (OXA88_14375) 3234525..3234869 - 345 WP_268169339.1 hypothetical protein Toxin
OXA88_RS14380 (OXA88_14380) 3235074..3235577 - 504 WP_015443887.1 hypothetical protein -
OXA88_RS14385 (OXA88_14385) 3235687..3236733 - 1047 WP_010948602.1 FAD-dependent oxidoreductase -
OXA88_RS14390 (OXA88_14390) 3237037..3237999 - 963 WP_015443886.1 lytic murein transglycosylase -
OXA88_RS14395 (OXA88_14395) 3238529..3239707 + 1179 WP_010948604.1 serine hydrolase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13249.12 Da        Isoelectric Point: 5.2063

>T265717 WP_268169339.1 NZ_CP113436:c3234869-3234525 [Legionella pneumophila]
MIFIETPIFTEDVKELLSDEEYAEFQEYLADNPLAGDVIQQTGKLANWQTGKLANCEKFDGHFKANGKRGGVRIIYYYVT
PASQIRLLLIYKKGIQDDLTTDQKKMLRQLNERW

Download         Length: 345 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.68 Da        Isoelectric Point: 8.0670

>AT265717 WP_010948599.1 NZ_CP113436:c3234522-3234232 [Legionella pneumophila]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVSIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAG

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References