265716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2608817..2610060 Replicon chromosome
Accession NZ_CP113436
Organism Legionella pneumophila strain PATHC021

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag OXA88_RS11545 Protein ID WP_010948074.1
Coordinates 2609122..2610060 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag OXA88_RS11540 Protein ID WP_010948073.1
Coordinates 2608817..2609125 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA88_RS11510 (OXA88_11510) 2604253..2604618 + 366 WP_010948069.1 BRCT domain-containing protein -
OXA88_RS11515 (OXA88_11515) 2604975..2605340 - 366 WP_010948070.1 TraK family protein -
OXA88_RS11520 (OXA88_11520) 2605525..2605665 - 141 WP_153802426.1 hypothetical protein -
OXA88_RS11525 (OXA88_11525) 2605668..2607419 - 1752 WP_010948071.1 DUF927 domain-containing protein -
OXA88_RS11530 (OXA88_11530) 2607485..2607760 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
OXA88_RS11535 (OXA88_11535) 2608593..2608820 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
OXA88_RS11540 (OXA88_11540) 2608817..2609125 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
OXA88_RS11545 (OXA88_11545) 2609122..2610060 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
OXA88_RS11550 (OXA88_11550) 2610603..2611217 + 615 WP_010948075.1 hypothetical protein -
OXA88_RS11555 (OXA88_11555) 2611373..2611579 - 207 WP_015444115.1 hypothetical protein -
OXA88_RS11560 (OXA88_11560) 2611916..2613184 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
OXA88_RS11565 (OXA88_11565) 2613654..2613944 - 291 WP_223804318.1 hypothetical protein -
OXA88_RS11570 (OXA88_11570) 2613925..2614590 - 666 WP_015444114.1 hypothetical protein -
OXA88_RS11575 (OXA88_11575) 2614766..2614897 - 132 WP_015444112.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2602839..2604014 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T265716 WP_010948074.1 NZ_CP113436:2609122-2610060 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT265716 WP_010948073.1 NZ_CP113436:2608817-2609125 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
AlphaFold DB Q5ZSZ7

References