265715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2734985..2736228 Replicon chromosome
Accession NZ_CP113435
Organism Legionella pneumophila strain PATHC025

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag OXA87_RS12075 Protein ID WP_027224015.1
Coordinates 2735290..2736228 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A1E5JNB7
Locus tag OXA87_RS12070 Protein ID WP_027224016.1
Coordinates 2734985..2735293 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA87_RS12050 (OXA87_12050) 2730512..2731636 - 1125 WP_027224020.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
OXA87_RS12055 (OXA87_12055) 2732012..2733763 - 1752 WP_027224019.1 DUF927 domain-containing protein -
OXA87_RS12060 (OXA87_12060) 2733847..2734122 - 276 WP_027224018.1 helix-turn-helix domain-containing protein -
OXA87_RS12065 (OXA87_12065) 2734761..2734988 + 228 WP_027224017.1 helix-turn-helix transcriptional regulator -
OXA87_RS12070 (OXA87_12070) 2734985..2735293 + 309 WP_027224016.1 HipA N-terminal domain-containing protein Antitoxin
OXA87_RS12075 (OXA87_12075) 2735290..2736228 + 939 WP_027224015.1 lpg2370 family Dot/Icm T4SS effector Toxin
OXA87_RS12080 (OXA87_12080) 2736225..2736416 - 192 WP_032829667.1 hypothetical protein -
OXA87_RS12085 (OXA87_12085) 2736518..2736943 - 426 WP_027224014.1 helix-turn-helix domain-containing protein -
OXA87_RS12090 (OXA87_12090) 2736946..2737233 - 288 WP_027224013.1 type II toxin-antitoxin system HigB family toxin -
OXA87_RS12095 (OXA87_12095) 2737297..2738526 - 1230 WP_027224012.1 integrase family protein -
OXA87_RS12100 (OXA87_12100) 2738806..2739981 - 1176 WP_011947261.1 ISL3 family transposase -
OXA87_RS12105 (OXA87_12105) 2740034..2740309 - 276 WP_011947262.1 hypothetical protein -
OXA87_RS12110 (OXA87_12110) 2740313..2740543 - 231 WP_011947263.1 DUF2188 domain-containing protein -
OXA87_RS12115 (OXA87_12115) 2740640..2740837 + 198 WP_011947264.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36029.85 Da        Isoelectric Point: 9.1296

>T265715 WP_027224015.1 NZ_CP113435:2735290-2736228 [Legionella pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.49 Da        Isoelectric Point: 4.6017

>AT265715 WP_027224016.1 NZ_CP113435:2734985-2735293 [Legionella pneumophila]
MRKAYVSVNGIRAGILEELEGKKYQFTYLNDYQGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5JNB7

References