265714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2725063..2726306 Replicon chromosome
Accession NZ_CP113434
Organism Legionella pneumophila strain PATHC027

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag OXA89_RS12065 Protein ID WP_027224015.1
Coordinates 2725368..2726306 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A1E5JNB7
Locus tag OXA89_RS12060 Protein ID WP_027224016.1
Coordinates 2725063..2725371 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA89_RS12040 (OXA89_12040) 2720590..2721714 - 1125 WP_027224020.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
OXA89_RS12045 (OXA89_12045) 2722090..2723841 - 1752 WP_027224019.1 DUF927 domain-containing protein -
OXA89_RS12050 (OXA89_12050) 2723925..2724200 - 276 WP_027224018.1 helix-turn-helix domain-containing protein -
OXA89_RS12055 (OXA89_12055) 2724839..2725066 + 228 WP_027224017.1 helix-turn-helix transcriptional regulator -
OXA89_RS12060 (OXA89_12060) 2725063..2725371 + 309 WP_027224016.1 HipA N-terminal domain-containing protein Antitoxin
OXA89_RS12065 (OXA89_12065) 2725368..2726306 + 939 WP_027224015.1 lpg2370 family Dot/Icm T4SS effector Toxin
OXA89_RS12070 (OXA89_12070) 2726303..2726494 - 192 WP_032829667.1 hypothetical protein -
OXA89_RS12075 (OXA89_12075) 2726596..2727021 - 426 WP_027224014.1 helix-turn-helix domain-containing protein -
OXA89_RS12080 (OXA89_12080) 2727024..2727311 - 288 WP_027224013.1 type II toxin-antitoxin system HigB family toxin -
OXA89_RS12085 (OXA89_12085) 2727375..2728604 - 1230 WP_027224012.1 integrase family protein -
OXA89_RS12090 (OXA89_12090) 2728884..2730059 - 1176 WP_011947261.1 ISL3 family transposase -
OXA89_RS12095 (OXA89_12095) 2730112..2730387 - 276 WP_011947262.1 hypothetical protein -
OXA89_RS12100 (OXA89_12100) 2730391..2730621 - 231 WP_011947263.1 DUF2188 domain-containing protein -
OXA89_RS12105 (OXA89_12105) 2730718..2730915 + 198 WP_011947264.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36029.85 Da        Isoelectric Point: 9.1296

>T265714 WP_027224015.1 NZ_CP113434:2725368-2726306 [Legionella pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.49 Da        Isoelectric Point: 4.6017

>AT265714 WP_027224016.1 NZ_CP113434:2725063-2725371 [Legionella pneumophila]
MRKAYVSVNGIRAGILEELEGKKYQFTYLNDYQGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5JNB7

References