Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3302429..3303050 Replicon chromosome
Accession NZ_CP113433
Organism Legionella pneumophila strain PATHC034

Toxin (Protein)


Gene name higB Uniprot ID Q5ZRG7
Locus tag OXA92_RS14775 Protein ID WP_010948600.1
Coordinates 3302829..3303050 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OXA92_RS14770 Protein ID WP_010948599.1
Coordinates 3302429..3302719 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA92_RS14755 (OXA92_14755) 3298490..3299977 + 1488 WP_010948597.1 lpg2912 family Dot/Icm T4SS effector -
OXA92_RS14760 (OXA92_14760) 3300139..3301581 - 1443 WP_010948598.1 ATP-binding protein -
OXA92_RS14765 (OXA92_14765) 3301949..3302140 + 192 WP_014327021.1 hypothetical protein -
OXA92_RS14770 (OXA92_14770) 3302429..3302719 - 291 WP_010948599.1 helix-turn-helix domain-containing protein Antitoxin
OXA92_RS14775 (OXA92_14775) 3302829..3303050 - 222 WP_010948600.1 hypothetical protein Toxin
OXA92_RS14780 (OXA92_14780) 3303255..3303758 - 504 WP_015443887.1 hypothetical protein -
OXA92_RS14785 (OXA92_14785) 3303868..3304914 - 1047 WP_010948602.1 FAD-dependent oxidoreductase -
OXA92_RS14790 (OXA92_14790) 3305218..3306180 - 963 WP_015443886.1 lytic murein transglycosylase -
OXA92_RS14795 (OXA92_14795) 3306710..3307888 + 1179 WP_010948604.1 serine hydrolase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8288.46 Da        Isoelectric Point: 3.7468

>T265713 WP_010948600.1 NZ_CP113433:c3303050-3302829 [Legionella pneumophila]
MIFIETPIFTEDVKELLSDEEYAEFQEYLADNPLAGDVIQQTGKLANWQTAKSSMVISRQMGSEAVLELFIIM

Download         Length: 222 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.68 Da        Isoelectric Point: 8.0670

>AT265713 WP_010948599.1 NZ_CP113433:c3302719-3302429 [Legionella pneumophila]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVSIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAG

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5ZRG7

Antitoxin

Source ID Structure

References