265712

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2676836..2678079 Replicon chromosome
Accession NZ_CP113433
Organism Legionella pneumophila strain PATHC034

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag OXA92_RS11955 Protein ID WP_010948074.1
Coordinates 2677141..2678079 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag OXA92_RS11950 Protein ID WP_010948073.1
Coordinates 2676836..2677144 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXA92_RS11920 (OXA92_11920) 2672272..2672637 + 366 WP_010948069.1 BRCT domain-containing protein -
OXA92_RS11925 (OXA92_11925) 2672994..2673359 - 366 WP_010948070.1 TraK family protein -
OXA92_RS11930 (OXA92_11930) 2673544..2673684 - 141 WP_153802426.1 hypothetical protein -
OXA92_RS11935 (OXA92_11935) 2673687..2675438 - 1752 WP_010948071.1 DUF927 domain-containing protein -
OXA92_RS11940 (OXA92_11940) 2675504..2675779 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
OXA92_RS11945 (OXA92_11945) 2676612..2676839 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
OXA92_RS11950 (OXA92_11950) 2676836..2677144 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
OXA92_RS11955 (OXA92_11955) 2677141..2678079 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
OXA92_RS11960 (OXA92_11960) 2678622..2679236 + 615 WP_010948075.1 hypothetical protein -
OXA92_RS11965 (OXA92_11965) 2679392..2679598 - 207 WP_015444115.1 hypothetical protein -
OXA92_RS11970 (OXA92_11970) 2679935..2681203 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
OXA92_RS11975 (OXA92_11975) 2681673..2681963 - 291 WP_223804318.1 hypothetical protein -
OXA92_RS11980 (OXA92_11980) 2681944..2682609 - 666 WP_015444114.1 hypothetical protein -
OXA92_RS11985 (OXA92_11985) 2682785..2682916 - 132 WP_015444112.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2670858..2672033 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T265712 WP_010948074.1 NZ_CP113433:2677141-2678079 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT265712 WP_010948073.1 NZ_CP113433:2676836-2677144 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
PDB 7VKB
AlphaFold DB Q5ZSZ7

References