Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5133842..5134436 Replicon chromosome
Accession NZ_CP113432
Organism Pseudomonas sp. ZM23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OU419_RS23765 Protein ID WP_192400966.1
Coordinates 5134158..5134436 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OU419_RS23760 Protein ID WP_254476610.1
Coordinates 5133842..5134147 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU419_RS23745 (OU419_23745) 5130055..5130918 - 864 WP_254476612.1 integrase domain-containing protein -
OU419_RS23750 (OU419_23750) 5131521..5132678 - 1158 WP_254476611.1 STY4528 family pathogenicity island replication protein -
OU419_RS23760 (OU419_23760) 5133842..5134147 - 306 WP_254476610.1 HigA family addiction module antitoxin Antitoxin
OU419_RS23765 (OU419_23765) 5134158..5134436 - 279 WP_192400966.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OU419_RS23770 (OU419_23770) 5134489..5135481 - 993 WP_254476609.1 tyrosine-type recombinase/integrase -
OU419_RS23775 (OU419_23775) 5135478..5136770 - 1293 WP_254476608.1 hypothetical protein -
OU419_RS23780 (OU419_23780) 5137010..5138299 - 1290 WP_268172348.1 zonular occludens toxin domain-containing protein -
OU419_RS23785 (OU419_23785) 5138303..5138659 - 357 WP_254476845.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5117526..5146021 28495


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10618.10 Da        Isoelectric Point: 7.2453

>T265711 WP_192400966.1 NZ_CP113432:c5134436-5134158 [Pseudomonas sp. ZM23]
MILTFRCDETRQLFESGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGNRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11232.72 Da        Isoelectric Point: 4.4462

>AT265711 WP_254476610.1 NZ_CP113432:c5134147-5133842 [Pseudomonas sp. ZM23]
MATNGMRPIHPGEILRDEFLMELDMSPAALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References