Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4556657..4557259 Replicon chromosome
Accession NZ_CP113364
Organism Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag OU685_RS22095 Protein ID WP_001159628.1
Coordinates 4556948..4557259 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OU685_RS22090 Protein ID WP_000362050.1
Coordinates 4556657..4556947 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU685_RS22075 (4554150) 4554150..4555052 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
OU685_RS22080 (4555049) 4555049..4555684 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OU685_RS22085 (4555681) 4555681..4556610 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OU685_RS22090 (4556657) 4556657..4556947 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OU685_RS22095 (4556948) 4556948..4557259 - 312 WP_001159628.1 hypothetical protein Toxin
OU685_RS22100 (4557477) 4557477..4558406 + 930 WP_017441897.1 alpha/beta hydrolase -
OU685_RS22105 (4558492) 4558492..4558803 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OU685_RS22110 (4558800) 4558800..4559246 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
OU685_RS22115 (4559261) 4559261..4560202 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OU685_RS22120 (4560247) 4560247..4560684 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
OU685_RS22125 (4560681) 4560681..4561553 - 873 WP_000921423.1 virulence factor BrkB family protein -
OU685_RS22130 (4561547) 4561547..4562146 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T265700 WP_001159628.1 NZ_CP113364:c4557259-4556948 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT265700 WP_000362050.1 NZ_CP113364:c4556947-4556657 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References