Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 737134..737646 Replicon chromosome
Accession NZ_CP113266
Organism Streptococcus pneumoniae strain BC1

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag OS912_RS03635 Protein ID WP_000924721.1
Coordinates 737134..737388 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag OS912_RS03640 Protein ID WP_000388572.1
Coordinates 737392..737646 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS912_RS03620 (OS912_03625) 734235..734549 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
OS912_RS03625 (OS912_03630) 734574..735200 - 627 WP_000775048.1 guanylate kinase -
OS912_RS03630 (OS912_03635) 735330..736943 - 1614 WP_000404940.1 ribonuclease Y -
OS912_RS03635 (OS912_03640) 737134..737388 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
OS912_RS03640 (OS912_03645) 737392..737646 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS912_RS03645 (OS912_03650) 737884..738981 - 1098 WP_268233008.1 nucleotidyltransferase -
OS912_RS03650 (OS912_03655) 738991..739737 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
OS912_RS03655 (OS912_03660) 739840..740193 - 354 WP_050104816.1 ribosome silencing factor -
OS912_RS03660 (OS912_03665) 740206..740706 - 501 WP_000844696.1 cysteine hydrolase family protein -
OS912_RS03665 (OS912_03670) 740707..741300 - 594 WP_268233009.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
OS912_RS03670 (OS912_03675) 741300..741929 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
OS912_RS03675 (OS912_03680) 741981..742292 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T265673 WP_000924721.1 NZ_CP113266:c737388-737134 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT265673 WP_000388572.1 NZ_CP113266:c737646-737392 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References