Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 300808..301361 Replicon chromosome
Accession NZ_CP113264
Organism Streptomonospora nanhaiensis strain 12A09

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag OUQ99_RS01420 Protein ID WP_267950213.1
Coordinates 300808..301044 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OUQ99_RS01425 Protein ID WP_267947597.1
Coordinates 301041..301361 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUQ99_RS01400 (OUQ99_01400) 295889..297103 + 1215 WP_267947594.1 glycine betaine/L-proline ABC transporter ATP-binding protein -
OUQ99_RS01405 (OUQ99_01405) 297105..299069 + 1965 WP_267947595.1 ABC transporter permease subunit -
OUQ99_RS01410 (OUQ99_01410) 299194..300135 + 942 WP_267950212.1 glycine betaine ABC transporter substrate-binding protein -
OUQ99_RS01415 (OUQ99_01415) 300263..300502 - 240 WP_267947596.1 hypothetical protein -
OUQ99_RS01420 (OUQ99_01420) 300808..301044 + 237 WP_267950213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OUQ99_RS01425 (OUQ99_01425) 301041..301361 + 321 WP_267947597.1 helix-turn-helix transcriptional regulator Antitoxin
OUQ99_RS01430 (OUQ99_01430) 301414..303708 - 2295 WP_267947598.1 phosphoribosylformylglycinamidine synthase subunit PurL -
OUQ99_RS01435 (OUQ99_01435) 303781..304314 - 534 WP_267947599.1 hypothetical protein -
OUQ99_RS01440 (OUQ99_01440) 304346..305041 - 696 WP_267947600.1 phosphoribosylformylglycinamidine synthase subunit PurQ -
OUQ99_RS01445 (OUQ99_01445) 305433..305912 - 480 WP_267947601.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(3-65)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-92)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.1104

>T265670 WP_267950213.1 NZ_CP113264:300808-301044 [Streptomonospora nanhaiensis]
MVDTVAGSVVANLKELRPGSSSGTEVRILFAFDPWRSAILLVAGDESGRWKTWYREAIPRAECLYESYLTERREEVGR

Download         Length: 237 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12067.55 Da        Isoelectric Point: 7.2060

>AT265670 WP_267947597.1 NZ_CP113264:301041-301361 [Streptomonospora nanhaiensis]
MSGYRRWRDSGHLEKAVESSGGQEQFEEEVTRLRDRARAWRLVEMRKHRELSQSQVAQRMGVSVARVSQIESGDLSTRDV
LDRYVTALGGTLLIIADFGDEQMKVG

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References