Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2990800..2991308 Replicon chromosome
Accession NZ_CP113262
Organism Streptomyces cavourensis strain NA4

Toxin (Protein)


Gene name yoeB Uniprot ID N0CS17
Locus tag OUQ49_RS13020 Protein ID WP_015609077.1
Coordinates 2991048..2991308 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag OUQ49_RS13015 Protein ID WP_114931509.1
Coordinates 2990800..2991051 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUQ49_RS13005 (OUQ49_13005) 2986564..2988537 - 1974 WP_267941923.1 PQQ-binding-like beta-propeller repeat protein -
OUQ49_RS13010 (OUQ49_13010) 2988843..2990666 - 1824 WP_119824883.1 ABC-F family ATP-binding cassette domain-containing protein -
OUQ49_RS13015 (OUQ49_13015) 2990800..2991051 + 252 WP_114931509.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OUQ49_RS13020 (OUQ49_13020) 2991048..2991308 + 261 WP_015609077.1 Txe/YoeB family addiction module toxin Toxin
OUQ49_RS13025 (OUQ49_13025) 2991296..2992744 - 1449 WP_142229187.1 acyltransferase family protein -
OUQ49_RS13030 (OUQ49_13030) 2992991..2993734 + 744 WP_267941924.1 hypothetical protein -
OUQ49_RS13035 (OUQ49_13035) 2993773..2994444 - 672 WP_217690860.1 XRE family transcriptional regulator -
OUQ49_RS13040 (OUQ49_13040) 2994552..2995271 + 720 WP_267941925.1 class I SAM-dependent methyltransferase -
OUQ49_RS13045 (OUQ49_13045) 2995313..2995813 + 501 WP_114931513.1 DinB family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 87 a.a.        Molecular weight: 10452.79 Da        Isoelectric Point: 9.4245

>T265668 WP_015609077.1 NZ_CP113262:2991048-2991308 [Streptomyces cavourensis]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Download         Length: 261 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9313.44 Da        Isoelectric Point: 4.6892

>AT265668 WP_114931509.1 NZ_CP113262:2990800-2991051 [Streptomyces cavourensis]
MRTMTYTESRAKYAETLSAVVNDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIERLESGGGTVRE
LAE

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB N0CS17


Antitoxin

Source ID Structure

References